Reaction Details |
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Target | Acyl-CoA (8-3)-desaturase |
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Ligand | BDBM50362592 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_852948 (CHEMBL2154132) |
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IC50 | >100000000±n/a nM |
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Citation | Oballa, RM; Belair, L; Black, WC; Bleasby, K; Chan, CC; Desroches, C; Du, X; Gordon, R; Guay, J; Guiral, S; Hafey, MJ; Hamelin, E; Huang, Z; Kennedy, B; Lachance, N; Landry, F; Li, CS; Mancini, J; Normandin, D; Pocai, A; Powell, DA; Ramtohul, YK; Skorey, K; Sørensen, D; Sturkenboom, W; Styhler, A; Waddleton, DM; Wang, H; Wong, S; Xu, L; Zhang, L Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem54:5082-96 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acyl-CoA (8-3)-desaturase |
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Name: | Acyl-CoA (8-3)-desaturase |
Synonyms: | FADS1_RAT | Fads1 | Fatty acid desaturase 1 |
Type: | PROTEIN |
Mol. Mass.: | 52505.96 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_852948 |
Residue: | 447 |
Sequence: | MAPDPVQTPDPASAQLRQMRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSR
VISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRA
TVERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSLVPFTLCAVLLSTVQAQAGWL
QHDFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPL
FFALGKVLSVELGKEKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLA
WMLSFYVRVFFTYMPLLGLKGLLCLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVS
TQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESK
PLLTAFADIVYSLKESGQLWLDAYLHQ
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BDBM50362592 |
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n/a |
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Name | BDBM50362592 |
Synonyms: | CHEMBL1938870 |
Type | Small organic molecule |
Emp. Form. | C17H16BrFN6O4 |
Mol. Mass. | 467.249 |
SMILES | OC(=O)Cn1nnc(n1)-c1cc(no1)N1CCC(CC1)Oc1cc(F)ccc1Br |
Structure |
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