| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50392512 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_860684 (CHEMBL2168001) |
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| IC50 | 6.9±n/a nM |
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| Citation |  Harikrishnan, LS; Finlay, HJ; Qiao, JX; Kamau, MG; Jiang, J; Wang, TC; Li, J; Cooper, CB; Poss, MA; Adam, LP; Taylor, DS; Chen, AY; Yin, X; Sleph, PG; Yang, RZ; Sitkoff, DF; Galella, MA; Nirschl, DS; Van Kirk, K; Miller, AV; Huang, CS; Chang, M; Chen, XQ; Salvati, ME; Wexler, RR; Lawrence, RM Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors. J Med Chem55:6162-75 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50392512 |
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| n/a |
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| Name | BDBM50392512 |
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| Synonyms: | CHEMBL2152165 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25ClF5N3O2 |
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| Mol. Mass. | 553.951 |
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| SMILES | FC(F)C(F)(F)Oc1cc(F)cc(c1)[C@](Cc1ccccc1)(NC(=O)NC1CCCC1)c1ccc(Cl)cn1 |r| |
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| Structure | 
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