Reaction Details |
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Target | Tyrosyl-DNA phosphodiesterase 1 |
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Ligand | BDBM50425082 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_936620 (CHEMBL2319019) |
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IC50 | >111000±n/a nM |
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Citation | Conda-Sheridan, M; Reddy, PV; Morrell, A; Cobb, BT; Marchand, C; Agama, K; Chergui, A; Renaud, A; Stephen, AG; Bindu, LK; Pommier, Y; Cushman, M Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1). J Med Chem56:182-200 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosyl-DNA phosphodiesterase 1 |
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Name: | Tyrosyl-DNA phosphodiesterase 1 |
Synonyms: | TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1) |
Type: | Enzyme |
Mol. Mass.: | 68430.66 |
Organism: | Homo sapiens (Human) |
Description: | Q9NUW8 |
Residue: | 608 |
Sequence: | MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
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BDBM50425082 |
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n/a |
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Name | BDBM50425082 |
Synonyms: | CHEMBL2312910 |
Type | Small organic molecule |
Emp. Form. | C21H16N2O5 |
Mol. Mass. | 376.3621 |
SMILES | COC(=O)CC(=O)Nc1ccc2c3C(=O)c4ccccc4-c3n(C)c(=O)c2c1 |
Structure |
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