Reaction Details |
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Target | Coagulation factor VII |
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Ligand | BDBM50439478 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_979046 (CHEMBL2421099) |
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IC50 | 51±n/a nM |
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Citation | Bolton, SA; Sutton, JC; Anumula, R; Bisacchi, GS; Jacobson, B; Slusarchyk, WA; Treuner, UD; Wu, SC; Zhao, G; Pi, Z; Sheriff, S; Smirk, RA; Bisaha, S; Cheney, DL; Wei, A; Schumacher, WA; Hartl, KS; Liu, E; Zahler, R; Seiler, SM Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold. Bioorg Med Chem Lett23:5239-43 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor VII |
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Name: | Coagulation factor VII |
Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
Type: | Enzyme |
Mol. Mass.: | 51599.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 466 |
Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM50439478 |
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n/a |
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Name | BDBM50439478 |
Synonyms: | CHEMBL2417902 |
Type | Small organic molecule |
Emp. Form. | C29H30N6O4 |
Mol. Mass. | 526.5863 |
SMILES | CNc1ccc(c(n1)C(=O)Nc1ccc2c(N)nccc2c1)-c1ccc(cc1C(O)=O)C(=O)NCC(C)(C)C |
Structure |
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