| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
|---|
| Ligand | BDBM50447538 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1289411 (CHEMBL3116907) |
|---|
| IC50 | 3200±n/a nM |
|---|
| Citation |  Wang, Y; Yang, W; Finlay, HJ; Harikrishnan, LS; Jiang, J; Kamau, MG; Van Kirk, K; Nirschl, DS; Taylor, DS; Chen, AY; Yin, X; Sleph, PG; Yang, RZ; Huang, CS; Adam, LP; Lawrence, RM; Wexler, RR; Salvati, ME Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors. Bioorg Med Chem Lett24:860-4 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholesteryl ester transfer protein |
|---|
| Name: | Cholesteryl ester transfer protein |
|---|
| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54751.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11597 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
|
|
|
|---|
| BDBM50447538 |
|---|
| n/a |
|---|
| Name | BDBM50447538 |
|---|
| Synonyms: | CHEMBL3116157 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H18ClF8N3OS |
|---|
| Mol. Mass. | 607.946 |
|---|
| SMILES | Cc1sc(N[C@](Cc2ccccc2)(c2cc(F)cc(OC(F)(F)C(F)F)c2)c2ccc(Cl)cn2)nc1C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
