Reaction Details |
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Target | Nuclear receptor subfamily 1 group I member 2 |
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Ligand | BDBM50448505 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1294702 (CHEMBL3128699) |
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EC50 | >50000±n/a nM |
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Citation | Gentles, RG; Ding, M; Bender, JA; Bergstrom, CP; Grant-Young, K; Hewawasam, P; Hudyma, T; Martin, S; Nickel, A; Regueiro-Ren, A; Tu, Y; Yang, Z; Yeung, KS; Zheng, X; Chao, S; Sun, JH; Beno, BR; Camac, DM; Chang, CH; Gao, M; Morin, PE; Sheriff, S; Tredup, J; Wan, J; Witmer, MR; Xie, D; Hanumegowda, U; Knipe, J; Mosure, K; Santone, KS; Parker, DD; Zhuo, X; Lemm, J; Liu, M; Pelosi, L; Rigat, K; Voss, S; Wang, Y; Wang, YK; Colonno, RJ; Gao, M; Roberts, SB; Gao, Q; Ng, A; Meanwell, NA; Kadow, JF Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem57:1855-79 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor subfamily 1 group I member 2 |
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Name: | Nuclear receptor subfamily 1 group I member 2 |
Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
Type: | Nuclear receptor |
Mol. Mass.: | 49774.77 |
Organism: | Homo sapiens (Human) |
Description: | O75469 |
Residue: | 434 |
Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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BDBM50448505 |
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n/a |
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Name | BDBM50448505 |
Synonyms: | CHEMBL3126656 |
Type | Small organic molecule |
Emp. Form. | C36H46N6O6S |
Mol. Mass. | 690.852 |
SMILES | COc1ccc2-c3c(C4CCCCC4)c4ccc(cc4n3CC3(CC3c2c1)C(=O)N1CCN(CC1)C(=O)N(C)C)C(=O)NS(=O)(=O)N(C)C |
Structure |
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