| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor XI |
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| Ligand | BDBM289812 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Factor XIa Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 1444±n/a nM |
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| Comments | extracted |
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| Citation |  Lim, Y; Guo, Z; Ali, A; Edmondson, SD; Liu, W; Gallo-Etienne, GV; Wu, H; Gao, Y; Stamford, AW; Yu, Y; Kevin, NJ; Anand, R; Sha, D; Neelamkavil, SF; Hussain, Z; Kumar, P; Moningka, R; Duffy, JL; Xu, J; Jiang, Y; Chakrabarti, A; Sone, H Factor XIa inhibitors US Patent US10093683 Publication Date 10/9/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor XI |
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| Name: | Coagulation factor XI |
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| Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
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| Type: | Enzyme |
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| Mol. Mass.: | 70130.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03951 |
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| Residue: | 625 |
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| Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
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| BDBM289812 |
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| n/a |
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| Name | BDBM289812 |
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| Synonyms: | US10093683, Example 120a | US10093683, Example 120b | US10093683, Example 120c | US10093683, Example 120d |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27ClN4O6 |
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| Mol. Mass. | 563.001 |
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| SMILES | COC(=O)Nc1ccc(NC(=O)C(Cc2ccccc2)C(=O)N2CCC3(C2)OC(=O)Nc2ccc(Cl)cc32)cc1 |
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| Structure | 
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