| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
|---|
| Ligand | BDBM339408 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | RORgammat (LBD) Reporter Assay |
|---|
| IC50 | 45.0±n/a nM |
|---|
| Citation |  Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X; Cummings, MD; McClure, K; Tanis, V Quinolinyl modulators of RORγt US Patent US10201546 Publication Date 2/12/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor ROR-gamma |
|---|
| Name: | Nuclear receptor ROR-gamma |
|---|
| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 58218.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51449 |
|---|
| Residue: | 518 |
|---|
| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
|
|
|
|---|
| BDBM339408 |
|---|
| n/a |
|---|
| Name | BDBM339408 |
|---|
| Synonyms: | US10201546, Example 245c |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H20Cl2F3N3O2 |
|---|
| Mol. Mass. | 510.336 |
|---|
| SMILES | COc1nc2ccc(cc2c(Cl)c1CCC(F)(F)F)[C@](O)(c1cncn1C)c1ccc(Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
