Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM31903 |
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Substrate/Competitor | BDBM8959 |
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Meas. Tech. | AChE Inhibition Assay |
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pH | 8±n/a |
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Temperature | 298.15±n/a K |
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IC50 | >10000±n/a nM |
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Citation | Camps, P; Formosa, X; Galdeano, C; Muñoz-Torrero, D; Ramírez, L; Gómez, E; Isambert, N; Lavilla, R; Badia, A; Clos, MV; Bartolini, M; Mancini, F; Andrisano, V; Arce, MP; Rodríguez-Franco, MI; Huertas, O; Dafni, T; Luque, FJ Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. J Med Chem52:5365-79 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
Type: | Enzyme |
Mol. Mass.: | 67792.70 |
Organism: | Homo sapiens (Human) |
Description: | P22303 |
Residue: | 614 |
Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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BDBM31903 |
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BDBM8959 |
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Name | BDBM31903 |
Synonyms: | tricyclic ester, 11.HCl |
Type | Small organic molecule |
Emp. Form. | C21H18ClNO3 |
Mol. Mass. | 367.826 |
SMILES | CCOC(=O)c1ccc2nc(-c3ccc(Cl)cc3)c3CCCOc3c2c1 |
Structure |
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