| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50287463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1729706 (CHEMBL4144984) |
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| IC50 | 32±n/a nM |
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| Citation |  Wang, Y; Cai, W; Tang, T; Liu, Q; Yang, T; Yang, L; Ma, Y; Zhang, G; Huang, Y; Song, X; Orband-Miller, LA; Wu, Q; Zhou, L; Xiang, Z; Xiang, JN; Leung, S; Shao, L; Lin, X; Lobera, M; Ren, F From ROR?t Agonist to Two Types of ROR?t Inverse Agonists. ACS Med Chem Lett9:120-124 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50287463 |
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| n/a |
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| Name | BDBM50287463 |
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| Synonyms: | CHEMBL4163226 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19F3N2O3S |
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| Mol. Mass. | 472.479 |
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| SMILES | CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(-c3cccc(c3)C#N)c(c2)C(F)(F)F)cc1 |
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| Structure | 
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