| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutaminase liver isoform, mitochondrial |
|---|
| Ligand | BDBM50548670 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2022796 (CHEMBL4676609) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Soth, MJ; Le, K; Di Francesco, ME; Hamilton, MM; Liu, G; Burke, JP; Carroll, CL; Kovacs, JJ; Bardenhagen, JP; Bristow, CA; Cardozo, M; Czako, B; de Stanchina, E; Feng, N; Garvey, JR; Gay, JP; Do, MKG; Greer, J; Han, M; Harris, A; Herrera, Z; Huang, S; Giuliani, V; Jiang, Y; Johnson, SB; Johnson, TA; Kang, Z; Leonard, PG; Liu, Z; McAfoos, T; Miller, M; Morlacchi, P; Mullinax, RA; Palmer, WS; Pang, J; Rogers, N; Rudin, CM; Shepard, HE; Spencer, ND; Theroff, J; Wu, Q; Xu, A; Yau, JA; Draetta, G; Toniatti, C; Heffernan, TP; Jones, P Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties. J Med Chem63:12957-12977 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutaminase liver isoform, mitochondrial |
|---|
| Name: | Glutaminase liver isoform, mitochondrial |
|---|
| Synonyms: | 3.5.1.2 | GA | GLS | GLS2 | GLSL_HUMAN | Glutaminase liver isoform, mitochondrial | L-glutaminase | L-glutamine amidohydrolase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66331.64 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_117753 |
|---|
| Residue: | 602 |
|---|
| Sequence: | MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD
HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ
ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA
AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA
EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES
MV
|
|
|
|---|
| BDBM50548670 |
|---|
| n/a |
|---|
| Name | BDBM50548670 |
|---|
| Synonyms: | CHEMBL4741924 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H27F3N8O3 |
|---|
| Mol. Mass. | 532.5182 |
|---|
| SMILES | CNC(=O)c1cn(C[C@H](F)CCc2ccc(NC(=O)Cc3cc(OC4CC(F)(F)C4)cc(C)n3)nn2)nn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
