Reaction Details |
| Report a problem with these data |
Target | A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436 |
---|
Ligand | BDBM50571509 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2114931 (CHEMBL4823872) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Kingsley, LJ; He, X; McNeill, M; Nelson, J; Nikulin, V; Ma, Z; Lu, W; Zhou, VW; Manuia, M; Kreusch, A; Gao, MY; Witmer, D; Vaillancourt, MT; Lu, M; Greenblatt, S; Lee, C; Vashisht, A; Bender, S; Spraggon, G; Michellys, PY; Jia, Y; Haling, JR; Lelais, G Structure-Based Design of Selective LONP1 Inhibitors for Probing J Med Chem64:4857-4869 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436 |
---|
Name: | A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436 |
Synonyms: | 20S proteasome | 26S proteosome |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | Combinations of UniProts |
Components: | This complex has 19 components. |
Component 1 |
Name: | Proteasome subunit beta type-2 |
Synonyms: | 20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit |
Type: | PROTEIN |
Mol. Mass.: | 22837.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1294233 |
Residue: | 201 |
Sequence: | MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY
LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV
RIIDKNGIHDLDNISFPKQGS
|
|
|
Component 2 |
Name: | Proteasome subunit beta type-1 |
Synonyms: | PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5 |
Type: | PROTEIN |
Mol. Mass.: | 26493.62 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1366691 |
Residue: | 241 |
Sequence: | MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG
FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML
STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ
VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK
D
|
|
|
Component 3 |
Name: | Proteasome subunit beta type-5 |
Synonyms: | 20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X |
Type: | Protein |
Mol. Mass.: | 28480.96 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 263 |
Sequence: | MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
|
|
|
Component 4 |
Name: | Proteasome subunit beta type-8 |
Synonyms: | 26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2 |
Type: | PROTEIN |
Mol. Mass.: | 30357.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1446797 |
Residue: | 276 |
Sequence: | MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
|
|
|
Component 5 |
Name: | Proteasome subunit beta type-9 |
Synonyms: | LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein |
Type: | PROTEIN |
Mol. Mass.: | 23256.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 219 |
Sequence: | MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
|
|
|
Component 6 |
Name: | Proteasome subunit beta type-6 |
Synonyms: | LMPY | Macropain delta chain | Multicatalytic endopeptidase complex delta chain | PSB6_HUMAN | PSMB6 | Proteasome delta chain | Proteasome subunit Y | Y |
Type: | PROTEIN |
Mol. Mass.: | 25349.89 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 239 |
Sequence: | MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
|
|
|
Component 7 |
Name: | Proteasome subunit alpha type-1 |
Synonyms: | 30 kDa prosomal protein | HC2 | Macropain subunit C2 | Multicatalytic endopeptidase complex subunit C2 | NU | PROS-30 | PROS30 | PSA1_HUMAN | PSC2 | PSMA1 | Proteasome component C2 | Proteasome nu chain |
Type: | PROTEIN |
Mol. Mass.: | 29555.77 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 263 |
Sequence: | MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ
KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT
QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM
ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP
QRKAQPAQPADEPAEKADEPMEH
|
|
|
Component 8 |
Name: | Proteasome subunit alpha type-2 |
Synonyms: | HC3 | Macropain subunit C3 | Multicatalytic endopeptidase complex subunit C3 | PSA2_HUMAN | PSC3 | PSMA2 | Proteasome component C3 |
Type: | PROTEIN |
Mol. Mass.: | 25900.29 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 234 |
Sequence: | MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER
SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE
YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE
DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
|
|
|
Component 9 |
Name: | Proteasome subunit alpha type-3 |
Synonyms: | HC8 | Macropain subunit C8 | Multicatalytic endopeptidase complex subunit C8 | PSA3_HUMAN | PSC8 | PSMA3 | Proteasome component C8 |
Type: | PROTEIN |
Mol. Mass.: | 28426.36 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 255 |
Sequence: | MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE
EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV
HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL
QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA
KESLKEEDESDDDNM
|
|
|
Component 10 |
Name: | Proteasome subunit alpha type-4 |
Synonyms: | HC9 | Macropain subunit C9 | Multicatalytic endopeptidase complex subunit C9 | PSA4_HUMAN | PSC9 | PSMA4 | Proteasome component C9 | Proteasome subunit L |
Type: | PROTEIN |
Mol. Mass.: | 29486.50 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 261 |
Sequence: | MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF
FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA
YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK
EGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKH
EEEEAKAEREKKEKEQKEKDK
|
|
|
Component 11 |
Name: | Proteasome subunit alpha type-5 |
Synonyms: | Macropain zeta chain | Multicatalytic endopeptidase complex zeta chain | PSA5_HUMAN | PSMA5 | Proteasome zeta chain |
Type: | PROTEIN |
Mol. Mass.: | 26398.14 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 241 |
Sequence: | MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME
PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA
LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS
LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD
I
|
|
|
Component 12 |
Name: | Proteasome subunit alpha type-6 |
Synonyms: | 27 kDa prosomal protein | Macropain iota chain | Multicatalytic endopeptidase complex iota chain | PROS-27 | PROS27 | PSA6_HUMAN | PSMA6 | Proteasome iota chain | p27K |
Type: | PROTEIN |
Mol. Mass.: | 27399.66 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 246 |
Sequence: | MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
ALAERD
|
|
|
Component 13 |
Name: | Proteasome subunit alpha type-7 |
Synonyms: | HSPC | PSA7_HUMAN | PSMA7 | Proteasome subunit RC6-1 | Proteasome subunit XAPC7 |
Type: | PROTEIN |
Mol. Mass.: | 27891.04 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 248 |
Sequence: | MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVR
KICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQ
SNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEA
IETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENE
KKKQKKAS
|
|
|
Component 14 |
Name: | Proteasome subunit alpha-type 8 |
Synonyms: | PSMA7L | PSMA8 | PSMA8_HUMAN | Proteasome subunit alpha type-7-like |
Type: | PROTEIN |
Mol. Mass.: | 28537.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 256 |
Sequence: | MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT
VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA
TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL
EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI
EKEKEEAEKKKSKKSV
|
|
|
Component 15 |
Name: | Proteasome subunit beta type-10 |
Synonyms: | LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i |
Type: | PROTEIN |
Mol. Mass.: | 28940.51 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 273 |
Sequence: | MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT
NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR
ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR
FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR
YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
|
|
|
Component 16 |
Name: | Proteasome subunit beta type-11 |
Synonyms: | PSB11_HUMAN | PSMB11 | Proteasome subunit beta-5t |
Type: | PROTEIN |
Mol. Mass.: | 32529.58 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 300 |
Sequence: | MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG
VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG
QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSG
SPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSD
ACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV
|
|
|
Component 17 |
Name: | Proteasome subunit beta type-3 |
Synonyms: | PSB3_HUMAN | PSMB3 | Proteasome chain 13 | Proteasome component C10-II | Proteasome theta chain |
Type: | PROTEIN |
Mol. Mass.: | 22948.68 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 205 |
Sequence: | MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV
QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF
ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV
SGMGVIVHIIEKDKITTRTLKARMD
|
|
|
Component 18 |
Name: | Proteasome subunit beta type-4 |
Synonyms: | 26 kDa prosomal protein | HsBPROS26 | HsN3 | Macropain beta chain | Multicatalytic endopeptidase complex beta chain | PROS-26 | PROS26 | PSB4_HUMAN | PSMB4 | Proteasome beta chain | Proteasome chain 3 |
Type: | PROTEIN |
Mol. Mass.: | 29202.40 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 264 |
Sequence: | MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK
FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE
LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP
SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK
GVEIEGPLSTETNWDIAHMISGFE
|
|
|
Component 19 |
Name: | Proteasome subunit beta type-7 |
Synonyms: | Macropain chain Z | Multicatalytic endopeptidase complex chain Z | PSB7_HUMAN | PSMB7 | Proteasome subunit Z | Z |
Type: | PROTEIN |
Mol. Mass.: | 29968.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 277 |
Sequence: | MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
|
|
|
BDBM50571509 |
---|
n/a |
---|
Name | BDBM50571509 |
Synonyms: | CHEMBL4861871 |
Type | Small organic molecule |
Emp. Form. | C15H25BN4O4 |
Mol. Mass. | 336.194 |
SMILES | CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CC(C)C)B(O)O |r| |
Structure |
|