| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM50593699 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2209828 (CHEMBL5122777) |
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| IC50 | 16±n/a nM |
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| Citation |  Cumming, IA; Degorce, SL; Aagaard, A; Braybrooke, EL; Davies, NL; Dične, CR; Eatherton, AJ; Felstead, HR; Groombridge, SD; Lenz, EM; Li, Y; Nai, Y; Pearson, S; Robb, GR; Scott, JS; Steward, OR; Wu, C; Xue, Y; Zhang, L; Zhang, Y Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors. Bioorg Med Chem63:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM50593699 |
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| n/a |
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| Name | BDBM50593699 |
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| Synonyms: | CHEMBL5171632 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28N8O |
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| Mol. Mass. | 420.5107 |
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| SMILES | [H][C@@]12CN(C)[C@@]([H])(C[C@@H]1n1cc(Nc3nc(NC4(C)CC4)c4c(ccn(C)c4=O)n3)cn1)C2 |r| |
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| Structure | 
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