| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Ligand | BDBM589235 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2212111 (CHEMBL5125060) |
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| IC50 | 400±n/a nM |
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| Citation |  Liu, Z; Duan, Z; Zhang, D; Xiao, P; Zhang, T; Xu, H; Wang, CH; Rao, GW; Gan, J; Huang, Y; Yang, CG; Dong, Z Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors. J Med Chem65:10638-10654 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58263.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1515854 |
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| Residue: | 505 |
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| Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
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| BDBM589235 |
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| n/a |
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| Name | BDBM589235 |
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| Synonyms: | US11555009, Compound 15 | US11555009, Compound 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14Cl2N2O3 |
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| Mol. Mass. | 377.221 |
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| SMILES | Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(O)=O)c(Cl)c1 |
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| Structure | 
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