Reaction Details |
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Target | Proteasome subunit beta type-8 |
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Ligand | BDBM50600773 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2234795 (CHEMBL5148567) |
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IC50 | >100000±n/a nM |
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Citation | Zhang, H; Ginn, J; Zhan, W; Liu, YJ; Leung, A; Toita, A; Okamoto, R; Wong, TT; Imaeda, T; Hara, R; Yukawa, T; Michino, M; Vendome, J; Beuming, T; Sato, K; Aso, K; Meinke, PT; Nathan, CF; Kirkman, LA; Lin, G Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors. J Med Chem65:9350-9375 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proteasome subunit beta type-8 |
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Name: | Proteasome subunit beta type-8 |
Synonyms: | 26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2 |
Type: | PROTEIN |
Mol. Mass.: | 30357.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1446797 |
Residue: | 276 |
Sequence: | MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
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BDBM50600773 |
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n/a |
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Name | BDBM50600773 |
Synonyms: | CHEMBL5174759 | US20240043470, Compound 3-08 |
Type | Small organic molecule |
Emp. Form. | C34H44N4O5 |
Mol. Mass. | 588.737 |
SMILES | O=C(NC1CCCC1)[C@@H]1CCCCOc2cccc(C[C@H](N3CCCC3=O)C(=O)N[C@@H](CCc3ccccc3)C(=O)N1)c2 |r| |
Structure |
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