Reaction Details |
| Report a problem with these data |
Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
---|
Ligand | BDBM50359768 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_791631 (CHEMBL1930855) |
---|
IC50 | 0.750000±n/a nM |
---|
Citation | Rawson, DJ; Ballard, S; Barber, C; Barker, L; Beaumont, K; Bunnage, M; Cole, S; Corless, M; Denton, S; Ellis, D; Floc'h, M; Foster, L; Gosset, J; Holmwood, F; Lane, C; Leahy, D; Mathias, J; Maw, G; Million, W; Poinsard, C; Price, J; Russel, R; Street, S; Watson, L The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg Med Chem20:498-509 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cGMP-specific 3',5'-cyclic phosphodiesterase |
---|
Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase |
Type: | Protein |
Mol. Mass.: | 99975.83 |
Organism: | Homo sapiens (Human) |
Description: | O76074 |
Residue: | 875 |
Sequence: | MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
|
|
|
BDBM50359768 |
---|
n/a |
---|
Name | BDBM50359768 |
Synonyms: | CHEMBL1928260 |
Type | Small organic molecule |
Emp. Form. | C27H34N8O5S |
Mol. Mass. | 582.674 |
SMILES | CCN1CCN(CC1)S(=O)(=O)c1cnc(OCc2ccccn2)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1 |
Structure |
|