| Reaction Details |
|---|
 | Report a problem with these data |
| Target | GTPase KRas [G12D] |
|---|
| Ligand | BDBM573341 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | KRas G12D Binding Assay |
|---|
| IC50 | 257±n/a nM |
|---|
| Citation |  Wang, X; Burns, AC; Christensen, JG; Ketcham, JM; Lawson, JD; Marx, MA; Smith, CR; Allen, S; Blake, JF; Chicarelli, MJ; Dahlke, JR; Dai, D; Fell, JB; Fischer, JP; Mejia, MJ; Newhouse, B; Nguyen, P; O''Leary, JM; Pajk, S; Rodriguez, ME; Savechenkov, P; Tang, TP; Vigers, GP; Zhao, Q; Kahn, DR; Gaudino, J; Hilton, MC KRas G12D inhibitors US Patent US11453683 Publication Date 9/27/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| GTPase KRas [G12D] |
|---|
| Name: | GTPase KRas [G12D] |
|---|
| Synonyms: | GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 21713.12 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P01116[G12D] |
|---|
| Residue: | 189 |
|---|
| Sequence: | MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
|
|
|
|---|
| BDBM573341 |
|---|
| n/a |
|---|
| Name | BDBM573341 |
|---|
| Synonyms: | US11453683, Example 68 | US20230279025, Example 68 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H28FN5O3 |
|---|
| Mol. Mass. | 489.5413 |
|---|
| SMILES | COCCCOc1nc(N2CC3CCC(C2)N3)c2cnc(c(F)c2n1)-c1cc(O)cc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
