| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-alpha [197-447] |
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| Ligand | BDBM20020 |
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| Substrate/Competitor | BDBM19993 |
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| Meas. Tech. | LXR Binding Assay |
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| pH | 7.4±n/a |
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| Temperature | 277.15±n/a K |
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| IC50 | 15.2±n/a nM |
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| Citation |  Hu, B; Jetter, J; Kaufman, D; Singhaus, R; Bernotas, R; Unwalla, R; Quinet, E; Savio, D; Halpern, A; Basso, M; Keith, J; Clerin, V; Chen, L; Liu, QY; Feingold, I; Huselton, C; Azam, F; Goos-Nilsson, A; Wilhelmsson, A; Nambi, P; Wrobel, J Further modification on phenyl acetic acid based quinolines as liver X receptor modulators. Bioorg Med Chem15:3321-33 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Oxysterols receptor LXR-alpha [197-447] |
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| Name: | Oxysterols receptor LXR-alpha [197-447] |
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| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 | Oxysterols receptor LXR-alpha |
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| Type: | Receptor |
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| Mol. Mass.: | 28986.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | LXR alpha ligand binding domain (amino acid residues 197-447) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays. |
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| Residue: | 251 |
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| Sequence: | SSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAH
FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL
KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL
QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLP
PLLSEIWDVHE
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| BDBM20020 |
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| BDBM19993 |
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| Name | BDBM20020 |
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| Synonyms: | 2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}propanoic acid | phenyl acetic acid based quinoline, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H25F3N2O3 |
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| Mol. Mass. | 554.5584 |
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| SMILES | CC(C(O)=O)c1ccc(CNc2cccc(c2)-c2c(cnc3c(cccc23)C(F)(F)F)C(=O)c2ccccc2)cc1 |
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| Structure | 
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