| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM20670 |
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| Substrate/Competitor | myelin basic protein |
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| Meas. Tech. | In Vitro Enzyme Inhibition Assay and Cell-based TNFalpha Biosynthesis Inhibition Assay |
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| Citation |  Hynes, J; Dyckman, AJ; Lin, S; Wrobleski, ST; Wu, H; Gillooly, KM; Kanner, SB; Lonial, H; Loo, D; McIntyre, KW; Pitt, S; Shen, DR; Shuster, DJ; Yang, X; Zhang, R; Behnia, K; Zhang, H; Marathe, PH; Doweyko, AM; Tokarski, JS; Sack, JS; Pokross, M; Kiefer, SE; Newitt, JA; Barrish, JC; Dodd, J; Schieven, GL; Leftheris, K Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors. J Med Chem51:4-16 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM20670 |
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| myelin basic protein |
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| Name: | myelin basic protein |
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| Synonyms: | myelin A1 protein |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 4541.90 |
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| Organism: | Oryctolagus cuniculus (rabbit) |
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| Description: | n/a |
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| Residue: | 42 |
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| Sequence: | fgsdrgapkr gsgkdhaart thygslpqks ghrpqdenpv vh
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