Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM24203 |
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Substrate/Competitor | BDBM24200 |
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Meas. Tech. | Epoxide Hydrolase Assay |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 11±8 nM |
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Citation | Grice, CA; Tays, KL; Savall, BM; Wei, J; Butler, CR; Axe, FU; Bembenek, SD; Fourie, AM; Dunford, PJ; Lundeen, K; Coles, F; Xue, X; Riley, JP; Williams, KN; Karlsson, L; Edwards, JP Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem51:4150-69 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM24203 |
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BDBM24200 |
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Name | BDBM24203 |
Synonyms: | 2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzoxazole | Benzoxazole compound, 10b |
Type | Small organic molecule |
Emp. Form. | C20H22N2O3 |
Mol. Mass. | 338.4003 |
SMILES | C(CN1CCCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 |
Structure |
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