| Reaction Details |
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 | Report a problem with these data |
| Target | Metallo-beta-lactamase type 2 |
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| Ligand | BDBM262467 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Class B Enzyme Assay |
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| pH | 7±n/a |
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| IC50 | 62.2±n/a nM |
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| Comments | extracted |
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| Citation |  Mandal, M; Tang, H; Xiao, L; Su, J; Li, G; Yang, S; Pan, W; Tang, H; DeJesus, R; Hicks, J; Lombardo, M; Chu, H; Hagmann, W; Pasternak, A; Gu, X; Jiang, J; Dong, S; Ding, F; London, C; Biswas, D; Young, K; Hunter, DN; Zhao, Z; Yang, D Metallo-beta-lactamase inhibitors US Patent US9708336 Publication Date 7/18/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Metallo-beta-lactamase type 2 |
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| Name: | Metallo-beta-lactamase type 2 |
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| Synonyms: | B2 metallo-beta-lactamase | BLA-IMP | BLAB_SERMA | Beta-lactamase type II | IMP-1 | Metallo-beta-lactamase type II |
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| Type: | undefined |
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| Mol. Mass.: | 27125.88 |
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| Organism: | Serratia marcescens |
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| Description: | P52699 |
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| Residue: | 246 |
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| Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
|
|
|
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| BDBM262467 |
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| n/a |
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| Name | BDBM262467 |
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| Synonyms: | 3-(quinolin-4-yl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide | US9708336, 319 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12N6O2S |
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| Mol. Mass. | 352.37 |
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| SMILES | NS(=O)(=O)c1cccc(-c2ccnc3ccccc23)c1-c1nn[nH]n1 |
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| Structure | 
|
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