| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK3 |
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| Ligand | BDBM28178 |
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| Substrate/Competitor | PLK Substrate Peptide |
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| Meas. Tech. | Scintillation Proximity Assay (SPA) |
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| pH | 7.2±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 9±n/a nM |
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| Citation |  Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg Med Chem Lett19:1694-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Serine/threonine-protein kinase PLK3 |
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| Name: | Serine/threonine-protein kinase PLK3 |
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| Synonyms: | CNK | Cytokine-inducible serine/threonine-protein kinase | FGF-inducible kinase | FNK | PLK3 | PLK3_HUMAN | PRK | Polo-Like Kinase 3 | Proliferation-related kinase | Serine/threonine-protein kinase PLK3 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 71655.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Enzyme assays were using PLK3 purified from baculovirus-infected Trichoplusia ni cells expressing full-length PLK3. |
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| Residue: | 646 |
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| Sequence: | MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR
TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR
HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG
ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE
ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR
DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN
HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG
FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL
SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME
QHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEP
LLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
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| BDBM28178 |
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| PLK Substrate Peptide |
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| Name: | PLK Substrate Peptide |
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| Synonyms: | n/a |
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| Type: | Biotinylated peptide |
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| Mol. Mass.: | 1720.29 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 15 |
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| Sequence: | |
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