| Reaction Details |
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 | Report a problem with these data |
| Target | Glucagon receptor |
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| Ligand | BDBM29129 |
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| Substrate/Competitor | 125I-Glucagon |
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| Meas. Tech. | SPA Receptor Binding Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 81±n/a nM |
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| Citation |  Madsen, P; Kodra, JT; Behrens, C; Nishimura, E; Jeppesen, CB; Pridal, L; Andersen, B; Knudsen, LB; Valcarce-Aspegren, C; Guldbrandt, M; Christensen, IT; Jørgensen, AS; Ynddal, L; Brand, CL; Bagger, MA; Lau, J Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties. J Med Chem52:2989-3000 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Glucagon receptor |
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| Name: | Glucagon receptor |
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| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54026.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47871 |
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| Residue: | 477 |
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| Sequence: | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
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| BDBM29129 |
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| 125I-Glucagon |
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| Name: | 125I-Glucagon |
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| Synonyms: | n/a |
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| Type: | radiolabeled peptide substrate |
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| Mol. Mass.: | 3483.25 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | n/a |
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| Residue: | 29 |
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| Sequence: | HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
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