Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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Ligand | BDBM34016 |
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Substrate/Competitor | BDBM34002 |
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Meas. Tech. | Pin1 Enzymatic Activity Assay |
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pH | 7.5±n/a |
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Temperature | 288.15±n/a K |
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Ki | 89±n/a nM |
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Citation | Guo, C; Hou, X; Dong, L; Dagostino, E; Greasley, S; Ferre, R; Marakovits, J; Johnson, MC; Matthews, D; Mroczkowski, B; Parge, H; Vanarsdale, T; Popoff, I; Piraino, J; Margosiak, S; Thomson, J; Los, G; Murray, BW Structure-based design of novel human Pin1 inhibitors (I). Bioorg Med Chem Lett19:5613-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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Name: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
Synonyms: | PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
Type: | PROTEIN |
Mol. Mass.: | 18248.11 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1502595 |
Residue: | 163 |
Sequence: | MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHL
LVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARG
DLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
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BDBM34016 |
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BDBM34002 |
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Name | BDBM34016 |
Synonyms: | 2,3-difluorophenylalanine derivative, 23b |
Type | Small organic molecule |
Emp. Form. | C18H16F2NO5PS |
Mol. Mass. | 427.359 |
SMILES | OP(O)(=O)OC[C@@H](Cc1cccc(F)c1F)NC(=O)c1cc2ccccc2s1 |r| |
Structure |
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