Found 137 hits with Last Name = 'mroczkowski' and Initial = 'b' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24485
(3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN3O4S/c1-32-23-14-18-20(15-24(23)33-2)28-11-10-21(18)34-22-9-8-17(13-19(22)27)29-26(35)30-25(31)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,29,30,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50184869
(1-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(2-p...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C26H23N3O4S/c1-31-23-15-20-21(16-24(23)32-2)27-13-12-22(20)33-19-10-8-18(9-11-19)28-26(34)29-25(30)14-17-6-4-3-5-7-17/h3-13,15-16H,14H2,1-2H3,(H2,28,29,30,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306682
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245264
(CHEMBL510112 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C25H22N4O4S/c1-31-21-13-18-19(14-22(21)32-2)26-11-10-20(18)33-24-9-8-17(15-27-24)28-25(34)29-23(30)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,28,29,30,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34012
(3-fluorophenylalanine derivative, 21b)Show SMILES OP(O)(=O)OC[C@@H](Cc1cccc(F)c1)NC(=O)c1cc2ccccc2s1 |r| Show InChI InChI=1S/C18H17FNO5PS/c19-14-6-3-4-12(8-14)9-15(11-25-26(22,23)24)20-18(21)17-10-13-5-1-2-7-16(13)27-17/h1-8,10,15H,9,11H2,(H,20,21)(H2,22,23,24)/t15-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6 | -45.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34011
(3-fluorophenylalanine derivative, 21a)Show SMILES OP(O)(=O)OC[C@@H](Cc1cccc(F)c1)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C20H19FNO5P/c21-18-7-3-4-14(10-18)11-19(13-27-28(24,25)26)22-20(23)17-9-8-15-5-1-2-6-16(15)12-17/h1-10,12,19H,11,13H2,(H,22,23)(H2,24,25,26)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8 | -44.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352534
(CHEMBL1824878)Show SMILES CC(Oc1cc(cnc1N)-c1ccc(cc1)C(=O)N1CCC[C@@H]1CN1CCCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C29H31Cl2FN4O2/c1-18(26-23(30)10-11-24(32)27(26)31)38-25-15-21(16-34-28(25)33)19-6-8-20(9-7-19)29(37)36-14-4-5-22(36)17-35-12-2-3-13-35/h6-11,15-16,18,22H,2-5,12-14,17H2,1H3,(H2,33,34)/t18?,22-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352559
(CHEMBL1825136)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCCNC1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)4-5-17(24)20(19)23)30-18-7-13(8-27-21(18)25)14-9-28-29(11-14)15-3-2-6-26-10-15/h4-5,7-9,11-12,15,26H,2-3,6,10H2,1H3,(H2,25,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306682
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352556
(CHEMBL1825133)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(CC2CN(CC(N)=O)C2)c1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C22H23Cl2FN6O2/c1-12(20-16(23)2-3-17(25)21(20)24)33-18-4-14(5-28-22(18)27)15-6-29-31(10-15)9-13-7-30(8-13)11-19(26)32/h2-6,10,12-13H,7-9,11H2,1H3,(H2,26,32)(H2,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352558
(CHEMBL1825135)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)[C@H]1CCNC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C20H20Cl2FN5O/c1-11(18-15(21)2-3-16(23)19(18)22)29-17-6-12(7-26-20(17)24)13-8-27-28(10-13)14-4-5-25-9-14/h2-3,6-8,10-11,14,25H,4-5,9H2,1H3,(H2,24,26)/t11?,14-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34013
(3-methylphenylalanine derivative, 22a)Show SMILES Cc1cccc(C[C@H](COP(O)(O)=O)NC(=O)c2ccc3ccccc3c2)c1 |r| Show InChI InChI=1S/C21H22NO5P/c1-15-5-4-6-16(11-15)12-20(14-27-28(24,25)26)22-21(23)19-10-9-17-7-2-3-8-18(17)13-19/h2-11,13,20H,12,14H2,1H3,(H,22,23)(H2,24,25,26)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 32 | -41.3 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352557
(CHEMBL1825134)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CNC1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C19H18Cl2FN5O/c1-10(17-14(20)2-3-15(22)18(17)21)28-16-4-11(5-25-19(16)23)12-6-26-27(9-12)13-7-24-8-13/h2-6,9-10,13,24H,7-8H2,1H3,(H2,23,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352540
(CHEMBL1824884)Show SMILES CC(Oc1cc(cnc1N)-c1ccc(cc1)C(=O)N1CCC(CC1)N1CCCC1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C29H31Cl2FN4O2/c1-18(26-23(30)8-9-24(32)27(26)31)38-25-16-21(17-34-28(25)33)19-4-6-20(7-5-19)29(37)36-14-10-22(11-15-36)35-12-2-3-13-35/h4-9,16-18,22H,2-3,10-15H2,1H3,(H2,33,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352551
(CHEMBL1821759)Show SMILES CC(C)n1cc(cn1)-c1cnc(N)c(OC(C)c2c(Cl)ccc(F)c2Cl)c1 Show InChI InChI=1S/C19H19Cl2FN4O/c1-10(2)26-9-13(8-25-26)12-6-16(19(23)24-7-12)27-11(3)17-14(20)4-5-15(22)18(17)21/h4-11H,1-3H3,(H2,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352560
(CHEMBL1825137)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCOCC1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C21H21Cl2FN4O2/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-26-21(18)25)14-10-27-28(11-14)15-4-6-29-7-5-15/h2-3,8-12,15H,4-7H2,1H3,(H2,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352542
(CHEMBL1824886)Show SMILES CC(Oc1cc(cnc1N)-c1ccc(cc1)C(=O)N1C[C@H](C)N[C@H](C)C1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C26H27Cl2FN4O2/c1-14-12-33(13-15(2)32-14)26(34)18-6-4-17(5-7-18)19-10-22(25(30)31-11-19)35-16(3)23-20(27)8-9-21(29)24(23)28/h4-11,14-16,32H,12-13H2,1-3H3,(H2,30,31)/t14-,15+,16? | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352550
(CHEMBL1824894)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(C)c1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C17H15Cl2FN4O/c1-9(15-12(18)3-4-13(20)16(15)19)25-14-5-10(6-22-17(14)21)11-7-23-24(2)8-11/h3-9H,1-2H3,(H2,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352554
(CHEMBL1825131)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(CC2(O)CCOCC2)c1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C22H23Cl2FN4O3/c1-13(19-16(23)2-3-17(25)20(19)24)32-18-8-14(9-27-21(18)26)15-10-28-29(11-15)12-22(30)4-6-31-7-5-22/h2-3,8-11,13,30H,4-7,12H2,1H3,(H2,26,27) | PDB
MMDB
KEGG
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B.MOAD
DrugBank
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PC sid
UniChem
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| Article
PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352553
(CHEMBL1825130)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(CC(=O)NCCCN(C)C)c1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C23H27Cl2FN6O2/c1-14(21-17(24)5-6-18(26)22(21)25)34-19-9-15(10-29-23(19)27)16-11-30-32(12-16)13-20(33)28-7-4-8-31(2)3/h5-6,9-12,14H,4,7-8,13H2,1-3H3,(H2,27,29)(H,28,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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PC sid
UniChem
Similars
| Article
PubMed
| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245431
(CHEMBL472552 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)c4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C24H20N4O5/c1-31-20-12-17-18(13-21(20)32-2)25-11-10-19(17)33-16-8-9-22(26-14-16)27-24(30)28-23(29)15-6-4-3-5-7-15/h3-14H,1-2H3,(H2,26,27,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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PC sid
UniChem
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| Article
PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34014
(3-methylphenylalanine derivative, 22b)Show SMILES Cc1cccc(C[C@H](COP(O)(O)=O)NC(=O)c2cc3ccccc3s2)c1 |r| Show InChI InChI=1S/C19H20NO5PS/c1-13-5-4-6-14(9-13)10-16(12-25-26(22,23)24)20-19(21)18-11-15-7-2-3-8-17(15)27-18/h2-9,11,16H,10,12H2,1H3,(H,20,21)(H2,22,23,24)/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
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| MMDB
PC cid
PC sid
PDB
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Similars
| MMDB
PDB
Article
PubMed
| 57 | -40.0 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352552
(CHEMBL1824895)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C(C)(C)C(=O)NCCN(C)C)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C24H29Cl2FN6O2/c1-14(20-17(25)6-7-18(27)21(20)26)35-19-10-15(11-30-22(19)28)16-12-31-33(13-16)24(2,3)23(34)29-8-9-32(4)5/h6-7,10-14H,8-9H2,1-5H3,(H2,28,30)(H,29,34) | PDB
MMDB
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UniChem
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| Article
PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352533
(CHEMBL1824877)Show SMILES CC(Oc1cc(cnc1N)-c1ccc(cc1)C(=O)N1CCC[C@@H]1CN1CCCC1)c1c(Cl)cccc1Cl |r| Show InChI InChI=1S/C29H32Cl2N4O2/c1-19(27-24(30)7-4-8-25(27)31)37-26-16-22(17-33-28(26)32)20-9-11-21(12-10-20)29(36)35-15-5-6-23(35)18-34-13-2-3-14-34/h4,7-12,16-17,19,23H,2-3,5-6,13-15,18H2,1H3,(H2,32,33)/t19?,23-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352555
(CHEMBL1825132)Show SMILES CC(Oc1cc(cnc1N)-c1cnn(CC2CNC2)c1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C20H20Cl2FN5O/c1-11(18-15(21)2-3-16(23)19(18)22)29-17-4-13(7-26-20(17)24)14-8-27-28(10-14)9-12-5-25-6-12/h2-4,7-8,10-12,25H,5-6,9H2,1H3,(H2,24,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352541
(CHEMBL1824885)Show SMILES CC(Oc1cc(cnc1N)-c1ccc(cc1)C(=O)NCCN1CCCC1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C26H27Cl2FN4O2/c1-16(23-20(27)8-9-21(29)24(23)28)35-22-14-19(15-32-25(22)30)17-4-6-18(7-5-17)26(34)31-10-13-33-11-2-3-12-33/h4-9,14-16H,2-3,10-13H2,1H3,(H2,30,32)(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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PC sid
UniChem
Patents
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| Article
PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34015
(2,3-difluorophenylalanine derivative, 23a)Show SMILES OP(O)(=O)OC[C@@H](Cc1cccc(F)c1F)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C20H18F2NO5P/c21-18-7-3-6-15(19(18)22)11-17(12-28-29(25,26)27)23-20(24)16-9-8-13-4-1-2-5-14(13)10-16/h1-10,17H,11-12H2,(H,23,24)(H2,25,26,27)/t17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 78 | -39.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245395
(CHEMBL461998 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)c4c(F)cccc4F)nc3)c2cc1OC Show InChI InChI=1S/C24H18F2N4O5/c1-33-19-10-14-17(11-20(19)34-2)27-9-8-18(14)35-13-6-7-21(28-12-13)29-24(32)30-23(31)22-15(25)4-3-5-16(22)26/h3-12H,1-2H3,(H2,28,29,30,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352548
(CHEMBL1824892)Show SMILES CC(Oc1cc(cnc1N)-c1cn[nH]c1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C16H13Cl2FN4O/c1-8(14-11(17)2-3-12(19)15(14)18)24-13-4-9(5-21-16(13)20)10-6-22-23-7-10/h2-8H,1H3,(H2,20,21)(H,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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PC sid
UniChem
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| Article
PubMed
| 82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34016
(2,3-difluorophenylalanine derivative, 23b)Show SMILES OP(O)(=O)OC[C@@H](Cc1cccc(F)c1F)NC(=O)c1cc2ccccc2s1 |r| Show InChI InChI=1S/C18H16F2NO5PS/c19-14-6-3-5-12(17(14)20)8-13(10-26-27(23,24)25)21-18(22)16-9-11-4-1-2-7-15(11)28-16/h1-7,9,13H,8,10H2,(H,21,22)(H2,23,24,25)/t13-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 89 | -38.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34009
(naphthalene carboxamide, 18a)Show SMILES OP(O)(=O)OC[C@@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C20H20NO5P/c22-20(18-11-10-16-8-4-5-9-17(16)13-18)21-19(14-26-27(23,24)25)12-15-6-2-1-3-7-15/h1-11,13,19H,12,14H2,(H,21,22)(H2,23,24,25)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 100 | -38.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352564
(CHEMBL1825141)Show SMILES C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
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| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 161 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34010
(benzothiophene carboxamide, 18b)Show SMILES OP(O)(=O)OC[C@@H](Cc1ccccc1)NC(=O)c1cc2ccccc2s1 |r| Show InChI InChI=1S/C18H18NO5PS/c20-18(17-11-14-8-4-5-9-16(14)26-17)19-15(12-24-25(21,22)23)10-13-6-2-1-3-7-13/h1-9,11,15H,10,12H2,(H,19,20)(H2,21,22,23)/t15-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| 179 | -37.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352546
(CHEMBL1824890)Show InChI InChI=1S/C16H12Cl2FN3O2/c1-8(14-11(17)2-3-12(19)15(14)18)24-13-4-9(5-21-16(13)20)10-6-22-23-7-10/h2-8H,1H3,(H2,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 201 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352549
(CHEMBL1824893)Show SMILES CC(Oc1cc(cnc1N)-c1c(C)n[nH]c1C)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C18H17Cl2FN4O/c1-8-15(9(2)25-24-8)11-6-14(18(22)23-7-11)26-10(3)16-12(19)4-5-13(21)17(16)20/h4-7,10H,1-3H3,(H2,22,23)(H,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352544
(CHEMBL1824888)Show SMILES CC(Oc1cc(cnc1N)-c1cn(C)cn1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C17H15Cl2FN4O/c1-9(15-11(18)3-4-12(20)16(15)19)25-14-5-10(6-22-17(14)21)13-7-24(2)8-23-13/h3-9H,1-2H3,(H2,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352532
(CHEMBL1824876)Show SMILES CC(Oc1cc(cnc1N)-c1ccc(cc1)C(=O)N1CCC[C@@H]1CN1CCCC1)c1c(F)ccc(F)c1Cl |r| Show InChI InChI=1S/C29H31ClF2N4O2/c1-18(26-23(31)10-11-24(32)27(26)30)38-25-15-21(16-34-28(25)33)19-6-8-20(9-7-19)29(37)36-14-4-5-22(36)17-35-12-2-3-13-35/h6-11,15-16,18,22H,2-5,12-14,17H2,1H3,(H2,33,34)/t18?,22-/m1/s1 | PDB
MMDB
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antibodypedia
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PC sid
UniChem
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| Article
PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352547
(CHEMBL1824891)Show SMILES CC(Oc1cc(cnc1N)-c1cc[nH]n1)c1c(Cl)ccc(F)c1Cl Show InChI InChI=1S/C16H13Cl2FN4O/c1-8(14-10(17)2-3-11(19)15(14)18)24-13-6-9(7-21-16(13)20)12-4-5-22-23-12/h2-8H,1H3,(H2,20,21)(H,22,23) | PDB
MMDB
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| Article
PubMed
| 348 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245311
(CHEMBL518511 | N-[5-(6,7-Dimethoxy-quinolin-4-ylox...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-21-13-18-19(14-22(21)30-2)25-11-10-20(18)31-17-8-9-23(26-15-17)27-24(28)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H,26,27,28) | PDB
MMDB
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352561
(CHEMBL1824866)Show SMILES Nc1ncc(cc1OCc1c(Cl)cccc1Cl)-c1ccc(cc1)C(=O)N1CCC[C@@H]1CN1CCCC1 |r| Show InChI InChI=1S/C28H30Cl2N4O2/c29-24-6-3-7-25(30)23(24)18-36-26-15-21(16-32-27(26)31)19-8-10-20(11-9-19)28(35)34-14-4-5-22(34)17-33-12-1-2-13-33/h3,6-11,15-16,22H,1-2,4-5,12-14,17-18H2,(H2,31,32)/t22-/m1/s1 | PDB
MMDB
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| Article
PubMed
| 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245393
(CHEMBL461119 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)CN4CCCC4)nc3)c2cc1OC Show InChI InChI=1S/C23H25N5O5/c1-31-19-11-16-17(12-20(19)32-2)24-8-7-18(16)33-15-5-6-21(25-13-15)26-23(30)27-22(29)14-28-9-3-4-10-28/h5-8,11-13H,3-4,9-10,14H2,1-2H3,(H2,25,26,27,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245394
(CHEMBL461120 | N-[({5-[(6,7-Dimethoxyquinolin-4-yl...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)CN4CCCCC4)nc3)c2cc1OC Show InChI InChI=1S/C24H27N5O5/c1-32-20-12-17-18(13-21(20)33-2)25-9-8-19(17)34-16-6-7-22(26-14-16)27-24(31)28-23(30)15-29-10-4-3-5-11-29/h6-9,12-14H,3-5,10-11,15H2,1-2H3,(H2,26,27,28,30,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34008
(amide, 17c)Show SMILES OP(O)(=O)OC[C@@H](Cc1ccccc1)NC(=O)c1ccccc1 |r| Show InChI InChI=1S/C16H18NO5P/c18-16(14-9-5-2-6-10-14)17-15(12-22-23(19,20)21)11-13-7-3-1-4-8-13/h1-10,15H,11-12H2,(H,17,18)(H2,19,20,21)/t15-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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UniChem
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PubMed
| 525 | -34.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352545
(CHEMBL1824889)Show InChI InChI=1S/C16H12Cl2FN3OS/c1-8(13-10(17)2-3-11(19)14(13)18)23-12-6-9(7-22-15(12)20)16-21-4-5-24-16/h2-8H,1H3,(H2,20,22) | PDB
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| Article
PubMed
| 780 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(Homo sapiens (Human)) | BDBM34005
(pipecolate deriv., 12b)Show SMILES OP(O)(=O)OC[C@@H](Cc1ccccc1)NC(=O)N1CCCC[C@H]1C(=O)OC(CCCc1ccccc1)CCCc1ccccc1 |r| Show InChI InChI=1S/C35H45N2O7P/c38-34(44-32(22-12-20-28-14-4-1-5-15-28)23-13-21-29-16-6-2-7-17-29)33-24-10-11-25-37(33)35(39)36-31(27-43-45(40,41)42)26-30-18-8-3-9-19-30/h1-9,14-19,31-33H,10-13,20-27H2,(H,36,39)(H2,40,41,42)/t31-,33+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| PC cid
PC sid
UniChem
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| Article
PubMed
| 800 | -33.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 15 |
Pfizer
| Assay Description
The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n... |
Bioorg Med Chem Lett 19: 5613-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.034
BindingDB Entry DOI: 10.7270/Q2XD100H |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352531
(CHEMBL1824875)Show SMILES Nc1ncc(cc1OCc1c(F)ccc(F)c1Cl)-c1ccc(cc1)C(=O)N1CCC[C@@H]1CN1CCCC1 |r| Show InChI InChI=1S/C28H29ClF2N4O2/c29-26-22(23(30)9-10-24(26)31)17-37-25-14-20(15-33-27(25)32)18-5-7-19(8-6-18)28(36)35-13-3-4-21(35)16-34-11-1-2-12-34/h5-10,14-15,21H,1-4,11-13,16-17H2,(H2,32,33)/t21-/m1/s1 | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352528
(CHEMBL1824872)Show SMILES CC(C)(C)c1ccc(COc2cc(cnc2N)-c2ccc(cc2)C(=O)N2CCC[C@@H]2CN2CCCC2)cc1 |r| Show InChI InChI=1S/C32H40N4O2/c1-32(2,3)27-14-8-23(9-15-27)22-38-29-19-26(20-34-30(29)33)24-10-12-25(13-11-24)31(37)36-18-6-7-28(36)21-35-16-4-5-17-35/h8-15,19-20,28H,4-7,16-18,21-22H2,1-3H3,(H2,33,34)/t28-/m1/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 980 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245392
(CHEMBL459892 | N-Benzyl-N0-{5-[(6,7-dimethoxyquino...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NCc4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C24H22N4O4/c1-30-21-12-18-19(13-22(21)31-2)25-11-10-20(18)32-17-8-9-23(26-15-17)28-24(29)27-14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H2,26,27,28,29) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50245351
(CHEMBL461118 | N-{5-[(6,7-Dimethoxyquinolin-4-yl)a...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NCCc4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C25H24N4O4/c1-31-22-14-19-20(15-23(22)32-2)26-13-11-21(19)33-18-8-9-24(28-16-18)29-25(30)27-12-10-17-6-4-3-5-7-17/h3-9,11,13-16H,10,12H2,1-2H3,(H2,27,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human activated c-Met by PK/LDH coupled kinetic assay |
Eur J Med Chem 43: 1321-9 (2008)
Article DOI: 10.1016/j.ejmech.2007.08.011
BindingDB Entry DOI: 10.7270/Q2HX1CGS |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50352539
(CHEMBL1824883)Show InChI InChI=1S/C19H15Cl2FN2O/c1-11(17-14(20)7-8-15(22)18(17)21)25-16-9-13(10-24-19(16)23)12-5-3-2-4-6-12/h2-11H,1H3,(H2,23,24) | PDB
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| CHEMBL
PC cid
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| Article
PubMed
| 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair | |
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