Reaction Details |
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Target | Zinc finger and BTB domain-containing protein 16 |
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Ligand | BDBM50239379 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1665992 (CHEMBL4015788) |
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IC50 | >30000±n/a nM |
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Citation | McCoull, W; Abrams, RD; Anderson, E; Blades, K; Barton, P; Box, M; Burgess, J; Byth, K; Cao, Q; Chuaqui, C; Carbajo, RJ; Cheung, T; Code, E; Ferguson, AD; Fillery, S; Fuller, NO; Gangl, E; Gao, N; Grist, M; Hargreaves, D; Howard, MR; Hu, J; Kemmitt, PD; Nelson, JE; O'Connell, N; Prince, DB; Raubo, P; Rawlins, PB; Robb, GR; Shi, J; Waring, MJ; Whittaker, D; Wylot, M; Zhu, X Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J Med Chem60:4386-4402 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Zinc finger and BTB domain-containing protein 16 |
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Name: | Zinc finger and BTB domain-containing protein 16 |
Synonyms: | PLZF | Promyelocytic leukemia zinc finger protein | ZBT16_HUMAN | ZBTB16 | ZNF145 | Zinc finger and BTB domain-containing protein 16 | Zinc finger protein 145 | Zinc finger protein PLZF |
Type: | PROTEIN |
Mol. Mass.: | 74272.31 |
Organism: | Homo sapiens |
Description: | ChEMBL_117331 |
Residue: | 673 |
Sequence: | MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFE
ILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLK
MLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPM
VDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAE
VKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGRE
ESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQP
ALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVE
QHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHR
QTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSH
TGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEK
PFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPD
WRIEKTYLYLCYV
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BDBM50239379 |
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n/a |
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Name | BDBM50239379 |
Synonyms: | CHEMBL4083842 |
Type | Small organic molecule |
Emp. Form. | C32H33ClN6O4 |
Mol. Mass. | 601.095 |
SMILES | [H][C@]12C[C@@H](CO)N(C1)c1cc(Nc3cc4CCC(=O)N(Cc5ccc(C)cc5)c4c(OC\C=C\CO2)c3)n2ncc(Cl)c2n1 |r,t:35| |
Structure |
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