Reaction Details |
| Report a problem with these data |
Target | Aldo-keto reductase family 1 member C4 |
---|
Ligand | BDBM50241828 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1670547 (CHEMBL4020435) |
---|
IC50 | 350±n/a nM |
---|
Citation | Endo, S; Xia, S; Suyama, M; Morikawa, Y; Oguri, H; Hu, D; Ao, Y; Takahara, S; Horino, Y; Hayakawa, Y; Watanabe, Y; Gouda, H; Hara, A; Kuwata, K; Toyooka, N; Matsunaga, T; Ikari, A Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells. J Med Chem60:8441-8455 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Aldo-keto reductase family 1 member C4 |
---|
Name: | Aldo-keto reductase family 1 member C4 |
Synonyms: | 3-alpha-HSD1 | 3-alpha-Hydroxysteroid Dehydrogenase Type 1 (AKR1C4) | 3-alpha-hydroxysteroid dehydrogenase type I | AK1C4_HUMAN | AKR1C4 | Aldo-keto reductase family 1 member C4 | Aldo-keto reductase family 1 member C4 (AK1C4) | CDR | CHDR | Chlordecone reductase | DD-4 | DD4 | Dihydrodiol dehydrogenase 4 | HAKRA |
Type: | Enzyme |
Mol. Mass.: | 37068.40 |
Organism: | Homo sapiens (Human) |
Description: | P17516 |
Residue: | 323 |
Sequence: | MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
|
|
|
BDBM50241828 |
---|
n/a |
---|
Name | BDBM50241828 |
Synonyms: | CHEMBL4089817 |
Type | Small organic molecule |
Emp. Form. | C19H16FNO4 |
Mol. Mass. | 341.333 |
SMILES | Oc1ccc2cc(C(=O)NCCCc3ccc(F)cc3)c(=O)oc2c1 |
Structure |
|