Reaction Details |
| Report a problem with these data |
Target | NAD-dependent protein deacetylase sirtuin-1 |
---|
Ligand | BDBM50242137 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1671335 (CHEMBL4021364) |
---|
IC50 | >300000±n/a nM |
---|
Citation | Yang, L; Ma, X; Yuan, C; He, Y; Li, L; Fang, S; Xia, W; He, T; Qian, S; Xu, Z; Li, G; Wang, Z Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors. Eur J Med Chem134:230-241 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
NAD-dependent protein deacetylase sirtuin-1 |
---|
Name: | NAD-dependent protein deacetylase sirtuin-1 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
Type: | Developmental protein; hydrolase |
Mol. Mass.: | 81626.66 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 747 |
Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
|
|
|
BDBM50242137 |
---|
n/a |
---|
Name | BDBM50242137 |
Synonyms: | CHEMBL4070149 |
Type | Small organic molecule |
Emp. Form. | C26H24N4O3S2 |
Mol. Mass. | 504.624 |
SMILES | Cc1cc(C)nc(SCC(=O)Nc2cccc(COc3ccc(NC(=O)c4cccs4)cc3)c2)n1 |
Structure |
|