Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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Ligand | BDBM50228363 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1671336 (CHEMBL4021365) |
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IC50 | 850±n/a nM |
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Citation | Yang, L; Ma, X; Yuan, C; He, Y; Li, L; Fang, S; Xia, W; He, T; Qian, S; Xu, Z; Li, G; Wang, Z Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors. Eur J Med Chem134:230-241 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
Synonyms: | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3 |
Type: | Protein |
Mol. Mass.: | 43582.69 |
Organism: | Homo sapiens (Human) |
Description: | Q9NTG7 |
Residue: | 399 |
Sequence: | MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
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BDBM50228363 |
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n/a |
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Name | BDBM50228363 |
Synonyms: | CHEMBL257991 | N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide | SRT-1720 |
Type | Small organic molecule |
Emp. Form. | C25H23N7OS |
Mol. Mass. | 469.561 |
SMILES | O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1 |
Structure |
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