| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50004185 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63655 |
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| pH | 7.5±n/a |
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| IC50 | 404±n/a nM |
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| Comments | extracted |
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| Citation |  Skiles, JW; Miao, C; Sorcek, R; Jacober, S; Mui, PW; Chow, G; Weldon, SM; Possanza, G; Skoog, M; Keirns, J Inhibition of human leukocyte elastase by N-substituted peptides containing alpha,alpha-difluorostatone residues at P1. J Med Chem35:4795-808 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50004185 |
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| n/a |
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| Name | BDBM50004185 |
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| Synonyms: | 4-[2-({2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-indan-2-yl-amino)-acetylamino]-2,2-difluoro-5-methyl-3-oxo-hexanoic acid ethyl ester | CHEMBL263927 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H43ClF2N4O9S |
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| Mol. Mass. | 817.295 |
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| SMILES | CCOC(=O)C(F)(F)C(=O)C(NC(=O)CN(C1Cc2ccccc2C1)C(=O)C(NC(=O)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1)C(C)C)C(C)C |
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| Structure | 
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