| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK2 |
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| Ligand | BDBM317462 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1681488 (CHEMBL4031765) |
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| IC50 | 15±n/a nM |
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| Citation |  Riggs, JR; Nagy, M; Elsner, J; Erdman, P; Cashion, D; Robinson, D; Harris, R; Huang, D; Tehrani, L; Deyanat-Yazdi, G; Narla, RK; Peng, X; Tran, T; Barnes, L; Miller, T; Katz, J; Tang, Y; Chen, M; Moghaddam, MF; Bahmanyar, S; Pagarigan, B; Delker, S; LeBrun, L; Chamberlain, PP; Calabrese, A; Canan, SS; Leftheris, K; Zhu, D; Boylan, JF The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J Med Chem60:8989-9002 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK2 |
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| Name: | Dual specificity protein kinase CLK2 |
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| Synonyms: | 2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 60128.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49760 |
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| Residue: | 499 |
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| Sequence: | MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQC
VDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMC
ISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN
SDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLD
WDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFA
RLRAEPPNKLWDSSRDISR
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| BDBM317462 |
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| n/a |
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| Name | BDBM317462 |
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| Synonyms: | 4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2- ylamino)-3-methoxy-N- methylbenzamide | US9623028, Compound 38 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28N6O4 |
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| Mol. Mass. | 512.5597 |
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| SMILES | CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(OC)c1 |
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| Structure | 
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