| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase A-Raf |
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| Ligand | BDBM50264719 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1699091 (CHEMBL4050073) |
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| IC50 | 25±n/a nM |
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| Citation |  Wang, L; Zhang, Q; Zhu, G; Zhang, Z; Zhi, Y; Zhang, L; Mao, T; Zhou, X; Chen, Y; Lu, T; Tang, W Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance. Eur J Med Chem130:86-106 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase A-Raf |
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| Name: | Serine/threonine-protein kinase A-Raf |
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| Synonyms: | ARAF | ARAF1 | ARAF_HUMAN | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | RAF serine/threonine protein kinase |
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| Type: | Enzyme |
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| Mol. Mass.: | 67610.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10398 |
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| Residue: | 606 |
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| Sequence: | MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
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| BDBM50264719 |
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| n/a |
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| Name | BDBM50264719 |
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| Synonyms: | CHEMBL4075036 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H35ClF3N7O2 |
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| Mol. Mass. | 630.104 |
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| SMILES | CN1CCN(CCCNc2cc(ncn2)C2(CC2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)CC1 |
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| Structure | 
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