| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM50267047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1701995 |
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| EC50 | 32000±n/a nM |
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| Citation |  Jurica, EA; Wu, X; Williams, KN; Hernandez, AS; Nirschl, DS; Rampulla, RA; Mathur, A; Zhou, M; Cao, G; Xie, C; Jacob, B; Cai, H; Wang, T; Murphy, BJ; Liu, H; Xu, C; Kunselman, LK; Hicks, MB; Sun, Q; Schnur, DM; Sitkoff, DF; Dierks, EA; Apedo, A; Moore, DB; Foster, KA; Cvijic, ME; Panemangalore, R; Flynn, NA; Maxwell, BD; Hong, Y; Tian, Y; Wilkes, JJ; Zinker, BA; Whaley, JM; Barrish, JC; Robl, JA; Ewing, WR; Ellsworth, BA Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode. J Med Chem60:1417-1431 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 57613.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37231 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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| BDBM50267047 |
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| n/a |
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| Name | BDBM50267047 |
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| Synonyms: | CHEMBL4078852 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21NO3 |
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| Mol. Mass. | 311.3749 |
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| SMILES | Cc1ccccc1Oc1ccc(cc1)N1CCC[C@H]1CC(O)=O |r| |
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| Structure | 
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