Ki Summary

Reaction Details

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Target

Bifunctional purine biosynthesis protein ATIC

Ligand

BDBM50005520

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_28425 (CHEMBL642468)

IC50

1900±n/a nM

Citation

Kelley, JL; McLean, EW; Cohn, NK; Edelstein, MP; Duch, DS; Smith, GK; Hanlon, MH; Ferone, R Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. J Med Chem33:561-7 (1990) [PubMed]

More Info.:

Get all data from this article, Assay Method

Bifunctional purine biosynthesis protein ATIC

Name:

Bifunctional purine biosynthesis protein ATIC

Synonyms:

AICAR transformylase | Atic | PUR9_MOUSE | Purh

Type:

PROTEIN

Mol. Mass.:

64218.64

Organism:

Mus musculus

Description:

ChEMBL_28425

Residue:

592

Sequence:

MAPSQLALFSVSDKTGLVEFARSLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLVRVVVCNLYPFVKTVASPDVTVEAA
VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYAGVAAEMHGSDSKDTSLETRRHLALKAFT
HTAQYDEAISDYFRKQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINL
CDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLA
VAYARARGADRMSSFGDFVALSDICDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNG
NYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIV
ATVAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKA
GVKRAEISNAIDQYVTGTIGEGEDLVKWEALFEEVPELLTEAEKKEWVDKLSGVSVSSDA
FFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH

BDBM50005520

n/a

Name

BDBM50005520

Synonyms:

(S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-propylamino]-benzoylamino}-pentanedioic acid | 2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-propylamino]-benzoylamino}-pentanedioic acid | CHEMBL13659

Type

Small organic molecule

Emp. Form.

C19H24N6O6

Mol. Mass.

432.4305

SMILES

Nc1nc(N)c(CCCNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c(=O)[nH]1

Structure