| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional purine biosynthesis protein ATIC |
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| Ligand | BDBM50014843 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28427 (CHEMBL642470) |
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| IC50 | 574000±n/a nM |
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| Citation |  Kelley, JL; McLean, EW; Cohn, NK; Edelstein, MP; Duch, DS; Smith, GK; Hanlon, MH; Ferone, R Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. J Med Chem33:561-7 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional purine biosynthesis protein ATIC |
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| Name: | Bifunctional purine biosynthesis protein ATIC |
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| Synonyms: | AICAR transformylase | Atic | PUR9_MOUSE | Purh |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64218.64 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_28425 |
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| Residue: | 592 |
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| Sequence: | MAPSQLALFSVSDKTGLVEFARSLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLVRVVVCNLYPFVKTVASPDVTVEAA
VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYAGVAAEMHGSDSKDTSLETRRHLALKAFT
HTAQYDEAISDYFRKQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINL
CDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLA
VAYARARGADRMSSFGDFVALSDICDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNG
NYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIV
ATVAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKA
GVKRAEISNAIDQYVTGTIGEGEDLVKWEALFEEVPELLTEAEKKEWVDKLSGVSVSSDA
FFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH
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| BDBM50014843 |
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| n/a |
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| Name | BDBM50014843 |
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| Synonyms: | 2-(4-{[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-propyl]-formyl-amino}-benzoylamino)-pentanedioic acid | CHEMBL152172 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N6O7 |
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| Mol. Mass. | 460.4406 |
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| SMILES | Nc1nc(N)c(CCCN(C=O)c2ccc(cc2)C(=O)NC(CCC(O)=O)C(O)=O)c(=O)[nH]1 |
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| Structure | 
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