| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50112600 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1729705 (CHEMBL4144983) |
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| IC50 | 200±n/a nM |
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| Citation |  Wang, Y; Cai, W; Tang, T; Liu, Q; Yang, T; Yang, L; Ma, Y; Zhang, G; Huang, Y; Song, X; Orband-Miller, LA; Wu, Q; Zhou, L; Xiang, Z; Xiang, JN; Leung, S; Shao, L; Lin, X; Lobera, M; Ren, F From ROR?t Agonist to Two Types of ROR?t Inverse Agonists. ACS Med Chem Lett9:120-124 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58133.31 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_103664 |
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| Residue: | 516 |
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| Sequence: | MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
CNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGS
GPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELG
EPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSR
EEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVL
VRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTA
LVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEK
LQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
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| BDBM50112600 |
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| n/a |
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| Name | BDBM50112600 |
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| Synonyms: | CHEMBL3609392 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19ClF3NO3S |
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| Mol. Mass. | 481.915 |
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| SMILES | CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(Cl)c2)-c2ccccc2C(F)(F)F)cc1 |
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| Structure | 
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