| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM50450230 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1742341 (CHEMBL4158091) |
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| EC50 | 62±n/a nM |
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| Citation |  Shinozuka, T; Tsukada, T; Fujii, K; Tokumaru, E; Shimada, K; Onishi, Y; Matsui, Y; Wakimoto, S; Kuroha, M; Ogata, T; Araki, K; Ohsumi, J; Sawamura, R; Watanabe, N; Yamamoto, H; Fujimoto, K; Tani, Y; Mori, M; Tanaka, J Discovery of DS-6930, a potent selective PPAR? modulator. Part I: Lead identification. Bioorg Med Chem26:5079-5098 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 57613.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37231 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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| BDBM50450230 |
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| n/a |
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| Name | BDBM50450230 |
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| Synonyms: | CHEMBL4174671 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20ClFN2O4 |
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| Mol. Mass. | 442.867 |
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| SMILES | Cl.Cc1cc(Oc2ccc3nc(COc4cccc(c4)C(O)=O)n(C)c3c2)ccc1F |
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| Structure | 
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