Reaction Details |
| Report a problem with these data |
Target | Mitogen-activated protein kinase 3 |
---|
Ligand | BDBM50458803 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1764717 (CHEMBL4199964) |
---|
IC50 | 20±n/a nM |
---|
Citation | Boga, SB; Deng, Y; Zhu, L; Nan, Y; Cooper, AB; Shipps, GW; Doll, R; Shih, NY; Zhu, H; Sun, R; Wang, T; Paliwal, S; Tsui, HC; Gao, X; Yao, X; Desai, J; Wang, J; Alhassan, AB; Kelly, J; Patel, M; Muppalla, K; Gudipati, S; Zhang, LK; Buevich, A; Hesk, D; Carr, D; Dayananth, P; Black, S; Mei, H; Cox, K; Sherborne, B; Hruza, AW; Xiao, L; Jin, W; Long, B; Liu, G; Taylor, SA; Kirschmeier, P; Windsor, WT; Bishop, R; Samatar, AA MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology. ACS Med Chem Lett9:761-767 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Mitogen-activated protein kinase 3 |
---|
Name: | Mitogen-activated protein kinase 3 |
Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 |
Type: | Protein |
Mol. Mass.: | 43136.58 |
Organism: | Homo sapiens (Human) |
Description: | curated by PDB 4QTB |
Residue: | 379 |
Sequence: | MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
|
|
|
BDBM50458803 |
---|
n/a |
---|
Name | BDBM50458803 |
Synonyms: | CHEMBL4213970 |
Type | Small organic molecule |
Emp. Form. | C37H41N9O3S |
Mol. Mass. | 691.845 |
SMILES | CS[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncn(C)n2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(OC(C)C)nc3)c2c1 |r,c:12| |
Structure |
|