Reaction Details |
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Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Ligand | BDBM50485077 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_816545 (CHEMBL2025125) |
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IC50 | 0.520000±n/a nM |
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Citation | Montgomery, JI; Brown, MF; Reilly, U; Price, LM; Abramite, JA; Arcari, J; Barham, R; Che, Y; Chen, JM; Chung, SW; Collantes, EM; Desbonnet, C; Doroski, M; Doty, J; Engtrakul, JJ; Harris, TM; Huband, M; Knafels, JD; Leach, KL; Liu, S; Marfat, A; McAllister, L; McElroy, E; Menard, CA; Mitton-Fry, M; Mullins, L; Noe, MC; O'Donnell, J; Oliver, R; Penzien, J; Plummer, M; Shanmugasundaram, V; Thoma, C; Tomaras, AP; Uccello, DP; Vaz, A; Wishka, DG Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections. J Med Chem55:1662-70 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
Synonyms: | LPXC_PSEAE | Protein envA | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-acyl-GlcNAc deacetylase | UDP-3-O-acyl-GlcNAc deacetylase (LpxC) | envA | lpxC |
Type: | Enzyme |
Mol. Mass.: | 33428.15 |
Organism: | Pseudomonas aeruginosa |
Description: | P47205 |
Residue: | 303 |
Sequence: | MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGET
TMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQ
EQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTS
FVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKIL
DAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPA
AAV
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BDBM50485077 |
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n/a |
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Name | BDBM50485077 |
Synonyms: | CHEMBL2023517 |
Type | Small organic molecule |
Emp. Form. | C17H17ClF2N2O5S |
Mol. Mass. | 434.842 |
SMILES | C[C@@](CCn1ccc(cc1=O)-c1ccc(Cl)c(F)c1F)(C(=O)NO)S(C)(=O)=O |r| |
Structure |
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