| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
|---|
| Ligand | BDBM444578 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1806445 (CHEMBL4305804) |
|---|
| IC50 | 1.0±n/a nM |
|---|
| Citation |  Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Han, Y; Xiao, W; Wang, Z; Shi, W; Mao, Y; Yu, J; Xia, G; Liu, Y Discovery of 6-(2-(dimethylamino)ethyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-6-yl)pyrimidin-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine as a highly potent cyclin-dependent kinase 4/6 inhibitor for treatment of cancer. Eur J Med Chem178:352-364 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
|---|
| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
|---|
| Synonyms: | CDK4/Cyclin D3 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 1806445 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 4 |
|---|
| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33731.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11802 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
|
|
|
|---|
| Component 2 |
| Name: | G1/S-specific cyclin-D3 |
|---|
| Synonyms: | CCND3 | CCND3_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32521.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30281 |
|---|
| Residue: | 292 |
|---|
| Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
|
|
|
|---|
| BDBM444578 |
|---|
| n/a |
|---|
| Name | BDBM444578 |
|---|
| Synonyms: | US10662186, Compound 98 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H34F2N8 |
|---|
| Mol. Mass. | 532.6307 |
|---|
| SMILES | CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCC5)c4c3)ccc2C1 |
|---|
| Structure | 
|
|---|
Search and Browse
