Reaction Details |
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Target | Nuclear receptor ROR-gamma |
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Ligand | BDBM50509564 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1838767 (CHEMBL4338900) |
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IC50 | 72±n/a nM |
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Citation | Zhang, H; Lapointe, BT; Anthony, N; Azevedo, R; Cals, J; Correll, CC; Daniels, M; Deshmukh, S; van Eenenaam, H; Ferguson, H; Hegde, LG; Karstens, WJ; Maclean, J; Miller, JR; Moy, LY; Simov, V; Nagpal, S; Oubrie, A; Palte, RL; Parthasarathy, G; Sciammetta, N; van der Stelt, M; Woodhouse, JD; Trotter, BW; Barr, K Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as ROR??t Allosteric Inhibitors for Autoimmune Diseases ACS Med Chem Lett11:114-119 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor ROR-gamma |
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Name: | Nuclear receptor ROR-gamma |
Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 58218.40 |
Organism: | Homo sapiens (Human) |
Description: | P51449 |
Residue: | 518 |
Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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BDBM50509564 |
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n/a |
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Name | BDBM50509564 |
Synonyms: | CHEMBL4584679 |
Type | Small organic molecule |
Emp. Form. | C22H11ClF4N2O3 |
Mol. Mass. | 462.781 |
SMILES | OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12 |
Structure |
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