| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neprilysin |
|---|
| Ligand | BDBM130359 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1839011 (CHEMBL4339144) |
|---|
| IC50 | 0.380000±n/a nM |
|---|
| Citation |  Kawanami, T; Karki, RG; Cody, E; Liu, Q; Liang, G; Ksander, GM; Rigel, DF; Schiering, N; Gong, Y; Coppola, GM; Iwaki, Y; Sun, R; Neubert, A; Fan, L; Ingles, S; D'Arcy, A; Villard, F; Ramage, P; Jeng, AY; Leung-Chu, J; Liu, J; Beil, M; Fu, F; Chen, W; Cumin, F; Wiesmann, C; Mogi, M Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors. ACS Med Chem Lett11:188-194 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neprilysin |
|---|
| Name: | Neprilysin |
|---|
| Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 85505.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08473 |
|---|
| Residue: | 750 |
|---|
| Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
|
|
|
|---|
| BDBM130359 |
|---|
| n/a |
|---|
| Name | BDBM130359 |
|---|
| Synonyms: | US8822534, Example 5-39 | US8993631, 5-8 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H22ClNO6 |
|---|
| Mol. Mass. | 419.855 |
|---|
| SMILES | COc1ccc(Cl)cc1-c1ccc(C[C@H](CC(O)=O)NC(=O)CCC(O)=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
