Reaction Details |
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Target | Reverse transcriptase/RNaseH |
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Ligand | BDBM50064009 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_196378 (CHEMBL802550) |
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IC50 | 44±n/a nM |
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Citation | Wishka, DG; Graber, DR; Kopta, LA; Olmsted, RA; Friis, JM; Hosley, JD; Adams, WJ; Seest, EP; Castle, TM; Dolak, LA; Keiser, BJ; Yagi, Y; Jeganathan, A; Schlachter, ST; Murphy, MJ; Cleek, GJ; Nugent, RA; Poppe, SM; Swaney, SM; Han, F; Watt, W; White, WL; Poel, TJ; Thomas, RC; Morris, J (-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor. J Med Chem41:1357-60 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase/RNaseH |
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Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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BDBM50064009 |
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n/a |
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Name | BDBM50064009 |
Synonyms: | 6-Chloro-2-(1-furo[2,3-c]pyridin-5-yl-ethylsulfanyl)-pyrimidin-4-ylamine | CHEMBL280752 |
Type | Small organic molecule |
Emp. Form. | C13H11ClN4OS |
Mol. Mass. | 306.771 |
SMILES | CC(Sc1nc(N)cc(Cl)n1)c1cc2ccoc2cn1 |
Structure |
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