| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50514603 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1857722 (CHEMBL4358451) |
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| IC50 | 5.4±n/a nM |
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| Citation |  Kazmierski, WM; Xia, B; Miller, J; De la Rosa, M; Favre, D; Dunham, RM; Washio, Y; Zhu, Z; Wang, F; Mebrahtu, M; Deng, H; Basilla, J; Wang, L; Evindar, G; Fan, L; Olszewski, A; Prabhu, N; Davie, C; Messer, JA; Samano, V DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors. J Med Chem63:3552-3562 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM50514603 |
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| n/a |
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| Name | BDBM50514603 |
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| Synonyms: | CHEMBL4550298 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25BrN4O4 |
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| Mol. Mass. | 513.384 |
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| SMILES | CCOC(=O)N1CCC2(CC1)C[C@H](NC(=O)c1cccc3cn[nH]c13)c1cc(Br)ccc1O2 |r| |
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| Structure | 
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