| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 4 group A member 2 |
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| Ligand | BDBM50517814 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1869815 (CHEMBL4370881) |
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| EC50 | 219±n/a nM |
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| Citation |  Lesuisse, D; Malanda, A; Peyronel, JF; Evanno, Y; Lardenois, P; De-Peretti, D; Abécassis, PY; Barnéoud, P; Brunel, P; Burgevin, MC; Cegarra, C; Auger, F; Dommergue, A; Lafon, C; Even, L; Tsi, J; Luc, TPH; Almario, A; Olivier, A; Castel, MN; Taupin, V; Rooney, T; Vigé, X Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease. Bioorg Med Chem Lett29:929-932 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 4 group A member 2 |
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| Name: | Nuclear receptor subfamily 4 group A member 2 |
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| Synonyms: | NOT | NR4A2 | NR4A2_HUMAN | NURR1 | TINUR |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66603.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_453027 |
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| Residue: | 598 |
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| Sequence: | MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSF
STFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSV
YYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQ
SPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHA
SQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCL
ANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSP
PVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGW
AEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFG
EWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVT
FNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
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| BDBM50517814 |
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| n/a |
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| Name | BDBM50517814 |
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| Synonyms: | CHEMBL4461137 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17ClN2O |
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| Mol. Mass. | 348.825 |
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| SMILES | CC(O)c1cccc(c1)-c1ccc2nc(cn2c1)-c1ccc(Cl)cc1 |
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| Structure | 
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