Reaction Details |
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Target | Renin |
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Ligand | BDBM50077686 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_195787 |
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IC50 | 26000±n/a nM |
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Citation | Vieira, E; Binggeli, A; Breu, V; Bur, D; Fischli, W; Güller, R; Hirth, G; Märki, HP; Müller, M; Oefner, C; Scalone, M; Stadler, H; Wilhelm, M; Wostl, W Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site. Bioorg Med Chem Lett9:1397-402 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50077686 |
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n/a |
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Name | BDBM50077686 |
Synonyms: | (3R,4R)-4-(4-Chloro-phenyl)-3-(4-methoxy-benzyloxy)-piperidine | CHEMBL31479 |
Type | Small organic molecule |
Emp. Form. | C19H22ClNO2 |
Mol. Mass. | 331.836 |
SMILES | COc1ccc(CO[C@H]2CNCC[C@@H]2c2ccc(Cl)cc2)cc1 |
Structure |
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