| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Renin |
|---|
| Ligand | BDBM50077709 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_195757 |
|---|
| IC50 | 3.3±n/a nM |
|---|
| Citation |  Güller, R; Binggeli, A; Breu, V; Bur, D; Fischli, W; Hirth, G; Jenny, C; Kansy, M; Montavon, F; Müller, M; Oefner, C; Stadler, H; Vieira, E; Wilhelm, M; Wostl, W; Märki, HP Piperidine-renin inhibitors compounds with improved physicochemical properties. Bioorg Med Chem Lett9:1403-8 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Renin |
|---|
| Name: | Renin |
|---|
| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45058.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 406 |
|---|
| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
|
|
|
|---|
| BDBM50077709 |
|---|
| n/a |
|---|
| Name | BDBM50077709 |
|---|
| Synonyms: | 4-{2-[(3S,4R,5R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-5-(naphthalen-2-ylmethoxy)-piperidin-3-ylmethoxy]-ethyl}-morpholine | CHEMBL31675 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C39H48N2O5 |
|---|
| Mol. Mass. | 624.8088 |
|---|
| SMILES | C(COCc1ccccc1)COc1ccc(cc1)[C@H]1[C@H](COCCN2CCOCC2)CNC[C@@H]1OCc1ccc2ccccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
