| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Discoidin domain-containing receptor 2 |
|---|
| Ligand | BDBM50529787 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1909870 (CHEMBL4412316) |
|---|
| IC50 | 2.9±n/a nM |
|---|
| Citation |  Wang, Q; Dai, Y; Ji, Y; Shi, H; Guo, Z; Chen, D; Chen, Y; Peng, X; Gao, Y; Wang, X; Chen, L; Jiang, Y; Geng, M; Shen, J; Ai, J; Xiong, B Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma. Eur J Med Chem163:671-689 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Discoidin domain-containing receptor 2 |
|---|
| Name: | Discoidin domain-containing receptor 2 |
|---|
| Synonyms: | DDR2 | DDR2_HUMAN | Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2) | NTRKR3 | TKT | TYRO10 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 96717.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16832 |
|---|
| Residue: | 855 |
|---|
| Sequence: | MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY
GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI
NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV
ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD
DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK
EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS
EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL
WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD
YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV
PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN
QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG
DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK
NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP
SFQEIHLLLLQQGDE
|
|
|
|---|
| BDBM50529787 |
|---|
| n/a |
|---|
| Name | BDBM50529787 |
|---|
| Synonyms: | CHEMBL4572126 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H22F3N5O2 |
|---|
| Mol. Mass. | 505.4911 |
|---|
| SMILES | Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(CCO)c1)C(=O)Nc1cccc(c1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
