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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histamine H3 receptor | ||
| Ligand | BDBM50535225 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1930022 (CHEMBL4433273) | ||
| Ki | 0.170000±n/a nM | ||
| Citation |  ?a?ewska, D; Kaleta, M; Schwed, JS; Karcz, T; Mogilski, S; Latacz, G; Olejarz, A; Siwek, A; Kubacka, M; Lubelska, A; Honkisz, E; Handzlik, J; Filipek, B; Stark, H; Kie?-Kononowicz, K Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H Bioorg Med Chem25:5341-5354 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histamine H3 receptor | |||
| Name: | Histamine H3 receptor | ||
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 48691.47 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. | ||
| Residue: | 445 | ||
| Sequence: |
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| BDBM50535225 | |||
| n/a | |||
| Name | BDBM50535225 | ||
| Synonyms: | CHEMBL4516622 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24N2 | ||
| Mol. Mass. | 316.4394 | ||
| SMILES | C[C@@H]1CCCN1[C@H]1C[C@@H](C1)c1ccc(cc1)-c1ccc(cc1)C#N |r,wU:8.11,1.0,wD:6.6,(34.83,-7.94,;35.15,-9.44,;34.11,-10.59,;34.88,-11.92,;36.39,-11.6,;36.55,-10.07,;37.88,-9.3,;39.37,-9.7,;39.77,-8.21,;38.28,-7.81,;41.1,-7.45,;41.1,-5.9,;42.43,-5.13,;43.77,-5.9,;43.77,-7.45,;42.43,-8.22,;45.09,-5.12,;46.43,-5.89,;47.76,-5.12,;47.75,-3.58,;46.41,-2.81,;45.08,-3.59,;49.08,-2.8,;50.41,-2.03,)| | ||
| Structure | 
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