| Reaction Details |
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 | Report a problem with these data |
| Target | Complement factor B |
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| Ligand | BDBM160036 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1981490 (CHEMBL4614752) |
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| IC50 | 18±n/a nM |
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| Citation |  Mainolfi, N; Ehara, T; Karki, RG; Anderson, K; Mac Sweeney, A; Liao, SM; Argikar, UA; Jendza, K; Zhang, C; Powers, J; Klosowski, DW; Crowley, M; Kawanami, T; Ding, J; April, M; Forster, C; Serrano-Wu, M; Capparelli, M; Ramqaj, R; Solovay, C; Cumin, F; Smith, TM; Ferrara, L; Lee, W; Long, D; Prentiss, M; De Erkenez, A; Yang, L; Liu, F; Sellner, H; Sirockin, F; Valeur, E; Erbel, P; Ostermeier, D; Ramage, P; Gerhartz, B; Schubart, A; Flohr, S; Gradoux, N; Feifel, R; Vogg, B; Wiesmann, C; Maibaum, J; Eder, J; Sedrani, R; Harrison, RA; Mogi, M; Jaffee, BD; Adams, CM Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases J Med Chem63:5697-5722 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement factor B |
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| Name: | Complement factor B |
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| Synonyms: | BF | BFD | CFAB_HUMAN | CFB |
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| Type: | Enzyme |
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| Mol. Mass.: | 85537.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00751 |
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| Residue: | 764 |
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| Sequence: | MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
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| BDBM160036 |
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| n/a |
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| Name | BDBM160036 |
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| Synonyms: | US10093663, Example 21a | US9682968, Example-21a |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N2O4 |
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| Mol. Mass. | 408.4901 |
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| SMILES | CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r| |
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| Structure | 
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